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phenobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers might raise the metabolism of ifosfamide to its Lively alkylating metabolites.On initiation or discontinuation of secukinumab in clients who will be obtaining concomitant CYP450 substrates, significantl